Recombinant Albumin

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by: clickthrough
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Date: Tue, 12 Oct 2010 Time: 12:13 PM
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Recombinant human albumin (rHA) has similar components to Albumin and is a highly purified animal-, virus-, and prion-free product developed as an alternative to human serum albumin (HSA).

Regular Albumin is at risk from contamination from virus's such as HIV & Hepititus but the development of Recombinant Albumin has enticed great interest as it is identical to natural blood.

Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum.
The product, proalbumin, is in turn cleaved in the Golgi vesicles to produce the secreted albumin. Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein.

Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Mutations in this gene on chromosome 4 result in various anomalous proteins.
Albumin is a globular unglycosylated serum protein of molecular weight 65,000. The human albumin gene is 16,961 nucleotides long from the putative 'cap' site to the first poly (A) addition site. It is split into 15 exons which are symmetrically placed within the 3 domains that are thought to have arisen by triplication of a single primordial domain.

About the Author

Mark Smith - Years of experience in biomanufacturing and process development. Areas of interest include bioproducts used in drug formulation and drug delivery. Applications of interest include Hyluronic Acid, Growth platforms and Albumin.

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For interviews, images or comments contact: Mark Smith
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Email: bnovozymes@gmail.com